6533b7dcfe1ef96bd1272b28
RESEARCH PRODUCT
Prenatal tobacco smoke exposure increases hospitalizations for bronchiolitis in infants
Lanari MVandini SAdorni FPrinelli FDi Santo SSilvestri MMusicco M” Faldella GSpinelli MCorsello GLa Forgia NLoprieno SBoldrini AVuerich MDel Vecchio AFabris CBertino EGaudino MCoscia AFanos VPuddu MGargano GBraibanti SCorso GOrfeo LDe Luca MgPaolillo PFabiano ABarberi IBarboni GMolinari LBonomi ALadetto LCarlucci AZorzi GDe Curtis MNatale FDi Fabio SFaccia PBottau PMacagno FEllero SMagaldi RRinaldi MMemo LNicolini GNgalikpima CjNosari NSarnelli PParmigiani SAgosti MNegri CCorona MfPiano FUmbaldo ADall’agnola AGirardi EGabriele BAurilia CRomagnoli Csubject
Pulmonary and Respiratory MedicineAdultmedicine.medical_specialtyPediatricsTime FactorsTime FactorOffspringLongitudinal StudieRisk AssessmentTobacco smoke exposure Pregnancy Infant Bronchiolitis Hospitalization Risk factorBronchiolitis; Hospitalization; Infant; Pregnancy; Risk factor; Tobacco smoke exposure; Adult; Age Factors; Bronchiolitis; Female; Humans; Infant; Infant Newborn; Inhalation Exposure; Italy; Longitudinal Studies; Maternal Exposure; Pregnancy; Risk Assessment; Risk Factors; Smoking; Time Factors; Tobacco Smoke Pollution; Hospitalization; Prenatal Exposure Delayed Effects; Pulmonary and Respiratory MedicineRisk FactorsPregnancymedicineHumansAge FactorLongitudinal StudiesBronchiolitiRisk factorIntensive care medicineInhalation exposurePregnancyInhalation Exposurebusiness.industryResearchSmokingAge FactorsInfant NewbornGestational ageInfantNewbornmedicine.diseaseHospitalizationItalyBronchiolitisMaternal ExposureTobacco smoke exposurePrenatal Exposure Delayed EffectsBronchiolitisFemaleTobacco Smoke PollutionRisk factorRisk assessmentbusinessHumanCohort studydescription
Background Tobacco smoke exposure (TSE) is a worldwide health problem and it is considered a risk factor for pregnant women’s and children’s health, particularly for respiratory morbidity during the first year of life. Few significant birth cohort studies on the effect of prenatal TSE via passive and active maternal smoking on the development of severe bronchiolitis in early childhood have been carried out worldwide. Methods From November 2009 to December 2012, newborns born at ≥33 weeks of gestational age (wGA) were recruited in a longitudinal multi-center cohort study in Italy to investigate the effects of prenatal and postnatal TSE, among other risk factors, on bronchiolitis hospitalization and/or death during the first year of life. Results Two thousand two hundred ten newborns enrolled at birth were followed-up during their first year of life. Of these, 120 (5.4 %) were hospitalized for bronchiolitis. No enrolled infants died during the study period. Prenatal passive TSE and maternal active smoking of more than 15 cigarettes/daily are associated to a significant increase of the risk of offspring children hospitalization for bronchiolitis, with an adjHR of 3.5 (CI 1.5–8.1) and of 1.7 (CI 1.1–2.6) respectively. Conclusions These results confirm the detrimental effects of passive TSE and active heavy smoke during pregnancy for infants’ respiratory health, since the exposure significantly increases the risk of hospitalization for bronchiolitis in the first year of life. Electronic supplementary material The online version of this article (doi:10.1186/s12931-015-0312-5) contains supplementary material, which is available to authorized users.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |