6533b7dcfe1ef96bd1273502
RESEARCH PRODUCT
Lipoprotein abnormalities in chronic kidney disease and renal transplantation
Maurizio AvernaDavide NotoRosalia CaldarellaEmilio NardiCarlo M. BarbagalloAntonina GiammancoMarcello CiaccioAngelo B. Cefalùsubject
medicine.medical_specialtyLipoproteins030232 urology & nephrologyDiseaseReview030204 cardiovascular system & hematologyurologic and male genital diseasesGastroenterologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineInternal medicineChronic kidney diseasemedicinelcsh:ScienceEcology Evolution Behavior and SystematicsKidneybusiness.industryHypertriglyceridemiaPaleontologymedicine.diseaseCardiovascular diseaseLipidsUremiafemale genital diseases and pregnancy complicationsTransplantationmedicine.anatomical_structureSpace and Planetary Sciencelipids (amino acids peptides and proteins)lcsh:QbusinessDyslipidemiaKidney diseaseLipoproteindescription
Chronic kidney disease (CKD) is one of the most important risk factors for cardiovascular disease (CVD). Despite the kidney having no direct implications for lipoproteins metabolism, advanced CKD dyslipidemia is usually present in patients with CKD, and the frequent lipid and lipoprotein alterations occurring in these patients play a role of primary importance in the development of CVD. Although hypertriglyceridemia is the main disorder, a number of lipoprotein abnormalities occur in these patients. Different enzymes pathways and proteins involved in lipoprotein metabolism are impaired in CKD. In addition, treatment of uremia may modify the expression of lipoprotein pattern as well as determine acute changes. In renal transplantation recipients, the main lipid alteration is hypercholesterolemia, while hypertriglyceridemia is less pronounced. In this review we have analyzed lipid and lipoprotein disturbances in CKD and also their relationship with progression of renal disease. Hypolipidemic treatments may also change the natural history of CVD in CKD patients and may represent important strategies in the management of CKD patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 |