6533b7defe1ef96bd1276782
RESEARCH PRODUCT
Dlk1 dosage regulates hippocampal neurogenesis and cognition
Valter TucciAnne C. Ferguson-smithSacri R. FerrónJosé Luis TrejoGiorgio VallortigaraAna Perez-villalbaAna Perez-villalbaAlexa E. HornerLisa M. SaksidaRaquel Montalbán-loroTimothy J. BusseyGlenda LassiGlenda LassiEsteban Jiménez-villalbaAnna Lozano-ureñaMarika Charalamboussubject
0301 basic medicinehippocampusHippocampusgene dosageBiologySubgranular zone03 medical and health sciencesMice0302 clinical medicineCognitionNeuroplasticitymedicineAnimalsEpigeneticsImprinting (psychology)AllelesMultidisciplinarybehaviorDentate gyrusNeurogenesisCalcium-Binding Proteinsneurogenesis genomic imprinting behavior gene dosage hippocampus424Biological Sciencesgenomic imprintingneurogenesis030104 developmental biologymedicine.anatomical_structurenervous systemGenomic imprintingNeuroscience030217 neurology & neurosurgeryNeurosciencedescription
Significance Generation of new neurons occurs normally in the adult brain in two locations: the subventricular zone (SVZ) in the walls of the lateral ventricles and the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus. Neurogenesis in the adult hippocampus has been implicated in cognitive functions such as learning, memory, and recovery of stress response. Imprinted genes are highly prevalent in the brain and have adult and developmental important functions. Genetic deletion of the imprinted gene Dlk1 from either parental allele shows that DLK1 is a key mediator of quiescence in adult hippocampal NSCs. Additionally, Dlk1 is exquisitely dosage sensitive in the brain with perturbations in levels resulting in impaired NSCs function and cognitive phenotypes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 |