6533b820fe1ef96bd127911a
RESEARCH PRODUCT
Effect of genetic variation in CYP450 on Gonadal impairment in a European cohort of female childhood cancer survivors, based on a candidate gene approach
M. E. Madeleine Van Der PerkLinda BroerYutaka YasuiLeslie L. RobisonMelissa M. HudsonJoop S. E. LavenHelena J. Van Der PalWim J. E. TissingBirgitta VersluysDorine BrestersGertjan J. L. KaspersAndrica C. H. De VriesCornelis B. LambalkAnnelies OverbeekJacqueline J. LoonenCatharina C. M. BeerendonkJulianne ByrneClaire BergerEva ClemensUta DirksenJeanette Falck WintherSophie D. FossåDesiree GrabowMonica MuracaMelanie KaiserTomáš KepákJarmila KruseovaDalit Modan-mosesClaudia SpixOliver ZolkPeter KaatschJesse H. KrijtheLeontien C. M. KremerRussell J. BrookeJessica L. BaedkeRon H. N. Van SchaikJohn N. Van Den AnkerAndré G. UitterlindenAnnelies M. E. BosFlora E. Van LeeuwenEline Van Dulmen-den BroederAnne-lotte L. F. Van Der KooiMarry M. Van Den Heuvel-eibrinkOn Behalf Of The Pancarelife Consortiumsubject
OncologyInfertilityCancer ResearchCandidate genemedicine.medical_specialtyendocrine systemendocrine system diseasesMedizinAnti-Müllerian hormoneArticleHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]Childhood cancer survivors03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingInterquartile rangeInternal medicineGenetic variationGenetic modelmedicineChemotherapyFertility preservationRC254-282030304 developmental biology0303 health sciencesbiologybusiness.industryNeoplasms. Tumors. Oncology. Including cancer and carcinogensAnti-Müllerian hormonemedicine.diseaseOvarian functionCytochrome P450 genesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]3. Good healthOncology030220 oncology & carcinogenesisCohortbiology.proteinCandidate gene approachbusinessGeneral Economics Econometrics and Financedescription
Background: Female childhood cancer survivors (CCSs) carry a risk of therapy-related gonadal dysfunction. Alkylating agents (AA) are well-established risk factors, yet inter-individual variability in ovarian function is observed. Polymorphisms in CYP450 enzymes may explain this variability in AA-induced ovarian damage. We aimed to evaluate associations between previously identified genetic polymorphisms in CYP450 enzymes and AA-related ovarian function among adult CCSs. Methods: Anti-Müllerian hormone (AMH) levels served as a proxy for ovarian function in a discovery cohort of adult female CCSs, from the pan-European PanCareLIFE cohort (n = 743
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 | Cancers |