6533b820fe1ef96bd12792d8

RESEARCH PRODUCT

Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Andrea PessionMariarita VetroMarta PillonPiero FarruggiaFrancesco LocatelliCaterina EliaRosamaria MuraClaudio FavreMarco ZeccaTommaso CasiniMaurizio BianchiAlessandra SalaNicola SantoroRoberta BurnelliMassimo ProvenziAntonella SauAlberto GaraventaGiuseppe PuccioAngela TrizzinoFrancesca RossiSalvatore D'amicoMaurizio MascarinSalvatore BuffardiGiulio Andrea Zanazzo

subject

MaleCancer Researchmedicine.medical_specialtyPrognostic factorMultivariate analysisAdolescent03 medical and health sciences0302 clinical medicineInternal medicineOutcome Assessment Health CaremedicineCutoffHumansPublic Health SurveillanceFavorable outcomeAge of OnsetChildchemotherapeutic approachesbusiness.industryAge FactorsDisease ManagementInfantHematologyPrognosisHodgkin DiseaseSurvival AnalysisNatural historypediatricOncologyItalyROC CurveSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA030220 oncology & carcinogenesisChild PreschoolLymphoma and Hodgkin diseaseHodgkin lymphomaDisease characteristicsFemalebusiness030215 immunology

description

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

yearjournalcountryeditionlanguage
2019-01-01
10.1080/10428194.2018.1493732https://hdl.handle.net/10807/229740