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RESEARCH PRODUCT
Gut inflammation in spondyloarthritis
Giuliana GugginoFrancesco CicciaAroldo RizzoAngelo Ferrantesubject
0301 basic medicineMacrophageSpondyloarthropathyInflammationSystemic inflammationPathogenesis03 medical and health sciences0302 clinical medicineRheumatologySpondylarthritismedicineHumansInnate lymphoid cellCytokineGut inflammationSubclinical infection030203 arthritis & rheumatologyInnate immunityInflammationAnkylosing spondylitisbusiness.industryInnate lymphoid cellPsoriatic arthritimedicine.diseaseUlcerative colitisDysbiosiGastrointestinal MicrobiomeIntestineIntestinesAnkylosing spondylitiSettore MED/16 - Reumatologia030104 developmental biologyImmunologymedicine.symptombusinessDysbiosisHumandescription
Abstract Spondyloarthritis (SpA) is a group of related diseases sharing common etiopathogenic mechanisms and clinical manifestations supported by a complex genetic predisposition. Gut inflammation is present in patients with SpA including patients showing clinically evident intestinal inflammation in the form of Crohn's disease or ulcerative colitis and patients who despite the absence of signs and symptoms of intestinal inflammation display a subclinical gut inflammation. Emerging evidence suggests that subclinical gut inflammation in patients with SpA, apparently driven by intestinal dysbiosis, is not the consequence of the systemic inflammatory process but rather an important pathophysiological event actively participating in the pathogenesis of the disease. The dysregulation of intestinal epithelial barrier possibly modulated by intestinal dysbiosis and especially in HLA-B27 + patients modulates local and systemic inflammation possibly representing the occult mechanism of the disease. This review aims to summarise current data on the role of the gastrointestinal involvement and intestinal microbiota in the pathogenesis of systemic rheumatic disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |