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RESEARCH PRODUCT
Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity
Marcus StockingerGerhardt FritzTheresa L. WhitesideHans-anton Lehr M.d.Maximilian MoergelJong-hyeon JeongMartin Kunkelsubject
AdultMaleOncologyendocrine systemCancer Researchmedicine.medical_specialtyPathologymedicine.medical_treatmentAntineoplastic AgentsRadiation ToleranceImmunoenzyme TechniquesRadioresistanceInternal medicineBiomarkers TumorHumansMedicineAgedRetrospective StudiesGlucose Transporter Type 1Chemotherapybusiness.industryProportional hazards modelHead and neck cancerMiddle AgedPrognosismedicine.diseaseCombined Modality TherapySurvival AnalysisNeoplasm ProteinsRadiation therapystomatognathic diseasesTreatment OutcomeOncologyEpidermoid carcinomaCarcinoma Squamous CellImmunohistochemistryFemaleMouth NeoplasmsHistopathologyOral Surgerybusinesshormones hormone substitutes and hormone antagonistsdescription
This study tested the hypothesis that GLUT-1 is a marker of radioresistance in oral squamous cell carcinomas (OSCC). A GLUT-1 labeling index (LI) was determined by immunohistochemistry in 40 pretreatment OSCC biopsies. Radiation responses were categorized by histopathology of the resection specimens. Associations between the LI and radiation response, Kaplan-Meier survival estimates and Cox regression analysis for the variables GLUT-1, T-stage, N-stage and chemotherapy were examined. The median LI was 64.2% (range 14-100%). Tumors with65% of GLUT-1+cells were more resistant to radiation (p=0.023). Overall survival was higher (p=0.044) for subjects with low LI (median value) than those with high LI (median value). The Cox regression analysis confirmed the prognostic significance of GLUT-1. Our results indicate that pre-treatment GLUT-1 expression in the tumor is a marker of radioresistance in OSCC, with high expression being associated with poor radiation response and shorter survival.
year | journal | country | edition | language |
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2006-08-11 | Oral Oncology |