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RESEARCH PRODUCT
Neutrophils: Between host defence, immune modulation, and tissue injury.
Markus P. RadsakHorst Von BernuthAlexander N.r. WeberPhilipp KrugerDirk RoosNikolaus RieberDominik HartlCharaf BenarafaMona SaffarzadehJulia Skokowasubject
lcsh:Immunologic diseases. AllergyChemokineCell SurvivalNeutrophilsPhagocytosisImmunologyInflammation610 Medicine & healthDiseaseReviewNeutropeniamedicine.disease_causeInfectionsMicrobiologyExtracellular TrapsImmune systemCell MovementVirologyGeneticsmedicineAnimalsHumansMolecular Biologylcsh:QH301-705.5InflammationMutationbiologyNeutrophil extracellular trapsmedicine.disease3. Good healthCell biologylcsh:Biology (General)Immunologybiology.proteinParasitologymedicine.symptomlcsh:RC581-607description
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-03-01 |