Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?

6533b823fe1ef96bd127eb29

RESEARCH PRODUCT

Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?

Sara Calatayud ÁNgeles ÁLvarez Victor M. Victor

subject

medicine.medical_specialty Inflammation digestive system Proinflammatory cytokine Gastric Acid Immunomodulation Internal medicine Drug Discovery Gastrins medicine Animals Humans Secretion Gastrin-Secreting Cells Protein Precursors Antrum Gastrin Cell Proliferation Pharmacology Chemistry digestive oral and skin physiology General Medicine Blockade Immunomodulatory peptide Endocrinology Gastrinoma Gastritis Receptors Cholecystokinin G cell medicine.symptom hormones hormone substitutes and hormone antagonists Signal Transduction

description

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

year	journal	country	edition	language
2010-04-13	Mini reviews in medicinal chemistry

10.2174/138955710791112532 https://pubmed.ncbi.nlm.nih.gov/20380639

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