6533b824fe1ef96bd127ff73

RESEARCH PRODUCT

Salivary levels of IgE and ECP in patients with recurrent aphthous stomatitis

Leila Farhad-mollashahiMarieh HonarmandShahram KamalzadehAlireza NakhaeeSanaz Amini

subject

Salivaeducation030204 cardiovascular system & hematologyImmunoglobulin ERecurrent aphthous stomatitisAtopy03 medical and health sciences0302 clinical medicinefluids and secretionsstomatognathic systemmedicine030212 general & internal medicineOral mucosaStomatitisGeneral DentistryEosinophil cationic proteinOral Medicine and Pathologybiologybusiness.industryResearchmedicine.disease:CIENCIAS MÉDICAS [UNESCO]stomatognathic diseasesmedicine.anatomical_structureImmunologyUNESCO::CIENCIAS MÉDICASbiology.proteinEtiologybusiness

description

Background Recurrent aphthous stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. Material and Methods In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p<0.05 was considered significant. Results The salivary levels of IgE and ECP were 1.11±0.65 Iu/ml and 26.93±6.95 ng/ml in the case group and 0.73±0/39 Iu/ml and 21.97±6.72 ng/ml in the control group. There was a significant difference between the two groups in terms of salivary levels of IgE and ECP (p=0.001). Conclusions The results showed that patients with oral aphthous had higher levels of salivary IgE and ECP than controls. Therefore, measurement of these biomarkers may be useful in the initial evaluation of patients with aphthous stomatitis. Key words:Recurrent aphthous stomatitis, saliva, immunoglobulin E, eosinophil cationic protein.

yearjournalcountryeditionlanguage
2019-09-01
https://hdl.handle.net/10550/75975