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RESEARCH PRODUCT
The Link Between Local Recurrence and Distant Metastases in Patients With Rectal Cancer.
Maria BlettnerDaniel WollschlaegerTong T. TrinhTheodor JungingerAndré LollertUrsula GoennerAchim Heintzsubject
MaleCancer Researchmedicine.medical_specialtyTime FactorsColorectal cancerAdenocarcinomaCompeting risksGastroenterologyRisk AssessmentInverse probability of treatment weighting03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineGermanymedicineHumansIn patientStage (cooking)AgedRetrospective StudiesProportional hazards modelbusiness.industryRectal NeoplasmsIncidence (epidemiology)IncidenceGeneral Medicinemedicine.diseaseTreatment OutcomeOncology030220 oncology & carcinogenesisCausal linkFemaleNeoplasm Recurrence Localbusinessdescription
BACKGROUND/AIM The relationships between local recurrence (LR), the development of distant metastases (DM) and prognosis in patients with rectal cancer remain unclear. PATIENTS AND METHODS In 606 patients who underwent curative resection, the role of LR was assessed retrospectively by time-dependent multivariate Cox models with inverse probability of treatment weighting taking into account competing risks. RESULTS Patients with LR had more DM than patients without LR (49/79, 62% vs. 86/524, 16.4%; p<0.001); 37% of LR-associated DM developed before or at LR, 63% after diagnosis of LR. Fifty-five percent of patients without DM at diagnosis of LR later developed DM. In these patients, the incidence of DM significantly exceeded the incidence in patients without LR. DM risk was most strongly associated with preceding LR and stage UICC III and II. CONCLUSION There is a causal link between LR and DM in patients with rectal cancer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-01 | Anticancer research |