6533b824fe1ef96bd1280c91
RESEARCH PRODUCT
Cardiovascular disease in aging: an overview on thoracic aortic aneurysm as an emerging inflammatory disease
Carmela Rita BalistreriAlessandro RicasoliGiovanni RuvoloCalogera Pisanosubject
0301 basic medicinemedicine.medical_specialtyPathologyAgingImmunologyMyocytes Smooth MuscleThoracic aortic aneurysm; acute aortic dissection; inflammatory pathwayReview Article030204 cardiovascular system & hematologyThoracic aortic aneurysmLesion03 medical and health sciencesAortic aneurysm0302 clinical medicineAneurysmmedicine.arteryInternal medicineThoracic aortic aneurysmAscending aortamedicinelcsh:PathologySettore MED/05 - Patologia ClinicaMyocyteHumansAortic dissectionInflammationAortaacute aortic dissectionAortic Aneurysm Thoracicbusiness.industrySettore MED/23 - Chirurgia CardiacaCell Biologymedicine.diseaseinflammatory pathway030104 developmental biologyCardiovascular DiseasesCardiologycardiovascular systemmedicine.symptombusinesslcsh:RB1-214description
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix. On the other hand, several inflammatory pathways (including TGF-β, TLR-4 interferon-γ, chemokines, and interferon-γ) seem to be involved in the medial degeneration related to aged and dilated aorta. This is an overview on thoracic aortic aneurysm as an emerging inflammatory disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-29 |