6533b827fe1ef96bd1287194
RESEARCH PRODUCT
Effects of 1-(halogenalkoxy)alkyl-5-fluorouracil derivatives on cell growth, cell volume and nucleus size of mouse lymphoma cells.
Reitz MKarl-heinz Jaegersubject
medicine.medical_specialtyLymphomaHydrochlorideDNA damageBiologychemistry.chemical_compoundMiceInternal medicineDrug DiscoverymedicineTumor Cells CulturedAnimalsPharmacology (medical)PharmacologyCell NucleusCell growthBiological activityGeneral Medicinemedicine.diseaseMolecular biologyIn vitroLymphomaInfectious Diseasesmedicine.anatomical_structureEndocrinologyOncologychemistryFluorouracilNucleusDNACell Divisiondescription
The effects of three 1-(halogenalkoxy)alkyl-5-fluorouracil derivatives on cultured mouse lymphoma cells were studied and compared with those of N-methyl-bis-(2-chloroethyl)amine hydrochloride (Lost). The derivatives exert only little influence on cell proliferation and cell volume. However, all derivatives cause a concentration-dependent nucleus contraction, probably due to DNA cross-linkings. Bromodesoxyuridine modulates the effects of the derivatives on the DNA, leading to swelling of the nucleus, which may be caused by DNA strand-breaks. It is suggested that the derivatives exert synergistic effects with other factors. It is concluded that these studies are suitable for the prescreening of agents to be investigated in mutagenicity tests.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Chemotherapy |