6533b828fe1ef96bd1288d4a

RESEARCH PRODUCT

Re: Does Oral Antiandrogen Use Before Leuteinizing Hormone-Releasing Therapy in Patients with Metastatic Prostate Cancer Prevent Clinical Consequences of a Testosterone Flare?

Michele Pavone-macaluso

subject

Oncologymedicine.medical_specialtyBicalutamideAntiandrogensmedicine.drug_classbusiness.industryUrologyUrologyurologic and male genital diseasesAntiandrogenmedicine.diseaseFlutamidechemistry.chemical_compoundProstate cancerchemistryInternal medicineNilutamidemedicineAntiandrogen Therapybusinesshormones hormone substitutes and hormone antagonistsLeuteinizing hormonemedicine.drug

description

Oh et al report their experience with 1566 metastatic prostate cancer patients treated with luteinising hormone-releasing hormone (LHRH) agonists in the area of Boston, Massachusetts, USA. Of these patients, 79.5% were given antiandrogens (bicalutamide, flutamide, or nilutamide) before the first LHRH agonist dose. The remaining patients (20.5%) did not receive antiandrogens. In all patients, complications appearing within 30 d and attributable to a flare phenomenon (fractures, spinal cord compression, bladder outlet obstruction, exacerbation of pain) were assessed retrospectively. Such complications were extremely rare ( or =7 d before starting the LHRH analogues) made no difference.The authors concluded that no evidence supports a generalised use of antiandrogens in addition to the LHRH agonists. The risks of antiandrogen therapy (hepatic,gastrointestinal, ocular, and pulmonary complications)may counterbalance the benefits of the combined therapy,which is much more expensive.

yearjournalcountryeditionlanguage
2010-08-01European Urology
https://doi.org/10.1016/j.eururo.2010.05.018