6533b829fe1ef96bd1289700
RESEARCH PRODUCT
ChemInform Abstract: Organocatalytic anti-Selective Mannich Reactions with Fluorinated Aldimines: Synthesis of anti-γ-Fluoroalkyl-γ-amino Alcohols.
Santos FusteroJose Luis AcenaMaria Dolores Perez CarrionFatemeh MojarradJuan F. Sanz-cerverasubject
chemistry.chemical_classificationchemistry.chemical_compoundAldimineTrimethylsilylchemistryOrganic chemistryEtherGeneral MedicineMannich reactionAdductCatalysisdescription
The asymmetric Mannich reaction between fluoroalkyl aldimines and aldehydes catalyzed by α,α-diphenylprolinol trimethylsilyl ether is reported. The corresponding Mannich adducts were reduced in situ to afford anti-β-alkyl-γ-fluoroalkyl-γ-amino alcohols in moderate yields and with very high diastereo- and enantioselectivities. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-02-16 | ChemInform |