6533b829fe1ef96bd128a3ba
RESEARCH PRODUCT
Gut-derived CD8+ tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients
Daniele MauroFederica MacalusoFrancesco CicciaAroldo RizzoGiuliana Gugginosubject
0301 basic medicineT cellImmunologyPopulationInflammationGeneral Biochemistry Genetics and Molecular BiologyCD49a03 medical and health sciences0302 clinical medicineRheumatologymedicineImmunology and AllergyeducationCytokine030203 arthritis & rheumatologyInflammationAnkylosing spondylitiseducation.field_of_studyAnkylosing Spondylitibusiness.industryCD29medicine.diseasePhenotypeSettore MED/16 - Reumatologia030104 developmental biologymedicine.anatomical_structureImmunologymedicine.symptombusinessCD8description
We read with interest the recently published paper from Qaiyum et al 1 demonstrating a novel integrin-expressing mature Crohn's disease (CD)8+ T cell population defined as CD49a+CD103+β7+CD29+ cells in the synovial fluids of ankylosing spondylitis (AS) patients. Although the authors did not analyse gut samples from AS patients, they speculate that these cells might be gut-derived cells. Interestingly, as stated by authors, the transcriptional and phenotypic signature of these cells is reminiscent of human tissue-resident memory T cells (TRM). TRM are a subset of cells important as the first line of defence from infection in mucosal tissues, never studied in spondyloarthritis (SpA).2 For clarifying whether these cells could be of intestinal original, we set up additional analyses, wondering if we could see similar results in paired samples of patients with SpA. Paired gut and synovial samples and fluids and peripheral blood samples (PCMCs) were obtained from patients with SpA (HLA-B27 positive; n=6), …
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-10-18 |