Early lipoic acid intake protects retina of diabetic mice

6533b829fe1ef96bd128adda

RESEARCH PRODUCT

Early lipoic acid intake protects retina of diabetic mice

Siv Johnsen-soriano Manuel Díaz-llopis Amparo Navea María Miranda Francisco Bosch-morell Salvador Garcia-delpech Francisco J. Romero María Sancho-tello Emma Arnal Maria Garcia-pous

subject

Male medicine.medical_specialty Antioxidant genetic structures medicine.medical_treatment medicine.disease_cause Biochemistry Antioxidants Drug Administration Schedule Retina Diabetes Mellitus Experimental Mice chemistry.chemical_compound Malondialdehyde Internal medicine Diabetes mellitus Alloxan Electroretinography medicine Animals Hypoglycemic Agents Insulin Glutathione Peroxidase Diabetic Retinopathy Thioctic Acid business.industry Insulin General Medicine Glutathione medicine.disease Glutathione eye diseases Oxidative Stress Lipoic acid Endocrinology chemistry lipids (amino acids peptides and proteins)sense organs business Erg Oxidative stress

description

The aim of this study was to test the effect of lipoic acid treatment on the retina after a short diabetic insult. Diabetes was induced by alloxan and mice were divided into sub-groups; control, diabetic, diabetic+insulin and all groups received+/-lipoic acid (100 mg/kg body weight) for 3 weeks. GSH content, MDA concentration, GPx activity were measured and electroretinograms (ERG) were recorded. Early administration of lipoic acid to diabetic mice prevented the statistically significant decreases of GSH content and GPx activity and normalized MDA concentration. Moreover, lipoic acid restored electroretinogram b-wave amplitude of diabetic animals to control values. Lipoic acid has a protective effect on the diabetic retina.

year	journal	country	edition	language
2008-07-09	Free Radical Research

https://doi.org/10.1080/10715760802206791

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