Mortality in COVID-19 disease patients: Correlating Association of Major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants

6533b82bfe1ef96bd128ce26

RESEARCH PRODUCT

Mortality in COVID-19 disease patients: Correlating Association of Major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants

Mohamed Osman Eric De Sousa Markus Maeurer Chiara Agrati Chao Zhang Sherif A. El-kafrawy Giuseppe Ippolito Alimuddin Zumla Esam I. Azhar Fu-sheng Wang Dário Ligeiro Joana R. Lérias

subject

0301 basic medicine cross-reactivity MHC binding Peptide binding medicine.disease_cause Autoimmunity 0302 clinical medicine 030212 general & internal medicine Mutation epitope autoimmunity General Medicine HLA Europe viral variants Infectious Diseases Coronavirus Infections Peptides ; COVID-19 ; Disease association ; Cross-reactivity ; MHC ; T-cells ; Autoimmunity ; Epitope ; Cytokines ; Viral variants ; HLA ; SARS ; SARS-CoV-2 ; MHC binding Microbiology (medical)Asia 030106 microbiology Pneumonia Viral Human leukocyte antigen Biology Major histocompatibility complex Article lcsh:Infectious and parasitic diseases 03 medical and health sciences Betacoronavirus MHC class I medicine Humans lcsh:RC109-216 Allele Pandemics Alleles SARS MHC class II SARS-CoV-2 T-cells disease association Histocompatibility Antigens Class I Histocompatibility Antigens Class II COVID-19 cytokines Immunology Africa biology.protein peptides MHC

description

Highlights • In addition to ethnicity, socio-economic factors, prior vaccinations and exposure to other coronaviruses, other factors need to be considered to explain geographical and regional variations in susceptibility, severity of clinical expression of COVID-19 disease and outcomes. • Differences in peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles frequent in individuals with African, Asian or Caucasian descent could be identified. • Single mutations in the wildtype of SARS-CoV-2, the so called B strain or L strain impact on MHC presentation • Most likely there is selective pressure from MHC class II alleles in regard to binding of the ORF8 (L84S) variants assuming that this mutation may be biologically relevant • MHC 4 – digit typing should be considered in studies examining clinical outcomes in patients with COVID-19.

year	journal	country	edition	language
2020-09-01	International Journal of Infectious Diseases

10.1016/j.ijid.2020.07.016 http://europepmc.org/articles/PMC7368421