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RESEARCH PRODUCT

Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

Marcelo Adrián MazzeoGustavo JarchumA. FinkelbergEvelin BachmeierMaría Marcela LópezFernando Martín WietzJ.a. Linares

subject

MaleSalivaPathologymedicine.medical_treatmentmedicine.disease_causeGastroenterologychemistry.chemical_compoundBasal (phylogenetics)Postoperative ComplicationsLongitudinal StudiesBone Marrow Transplantationchemistry.chemical_classificationbiology//purl.org/becyt/ford/3.1 [https]Middle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludMedicina BásicaUNESCO::CIENCIAS MÉDICASFemale//purl.org/becyt/ford/3 [https]AdultMucositismedicine.medical_specialtyCIENCIAS MÉDICAS Y DE LA SALUDOdontologíaFisiologíaSuperoxide dismutaseInternal medicinemedicineMucositisHumansSalivaGeneral DentistryAgedReactive oxygen speciesChemotherapyOral Medicine and Pathologybusiness.industrySuperoxide DismutaseResearchmedicine.diseaseUric AcidOtorhinolaryngologychemistrybiology.proteinUric acidSurgerybusinessOxidative stress

description

Objectives: High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva. Study Design: Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Depart- ment, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophoto- metric method, ( Trinder Color Kit , Wiener Lab) was used. Results: 85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values. Conclusions: SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of higher degrees of mucositis. Fil: Bachmeier, Evelin. Universidad Nacional de Cordoba. Facultad de Odontologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mazzeo, Marcelo Adrián. Universidad Nacional de Córdoba; Argentina Fil: López, María Marcela. Universidad Nacional de Cordoba. Facultad de Odontologia; Argentina Fil: Linares, Jorge Alberto. Universidad Nacional de Córdoba; Argentina Fil: Jarchum, Gustavo. Sanatorio Allende; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia; Argentina Fil: Wietz, Fernando Martín. Universidad Nacional de Cordoba. Facultad de Odontologia; Argentina Fil: Finkelberg, Ana Beatriz. Universidad Nacional de Cordoba. Facultad de Odontologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

yearjournalcountryeditionlanguage
2014-09-01
10.4317/medoral.19062http://www.medicinaoral.com/pubmed/medoralv19_i5_p444.pdf