Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma.

6533b82bfe1ef96bd128e0e5

RESEARCH PRODUCT

Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma.

Kyogo Itoh Christoph Rohde ÖZlem Türeci Ugur Sahin Rin Yamaguchi Svetlana Mukhina

subject

Cancer Research medicine.medical_specialty medicine.medical_treatment Population prevalence Adenocarcinoma Gastroenterology Asian People Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging education Lymph node IMAB362 Chemotherapy education.field_of_study biology business.industry gastric cancer Cancer Antibodies Monoclonal biomarkers General Medicine medicine.disease Immunohistochemistry Claudin Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Lymphatic Metastasis Claudins biology.protein Immunohistochemistry Biomarker (medicine)Original Article Antibody business

description

CLDN18.2 expression is highly prevalent in Japanese patients with gastric cancer, making it a targetable alteration, and supporting development of zolbetuximab as a therapeutic agent for this patient population.

year	journal	country	edition	language
2019-05-14	Japanese journal of clinical oncology

10.1093/jjco/hyz068 https://pubmed.ncbi.nlm.nih.gov/31087075

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