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RESEARCH PRODUCT
Cohort Profile: the EPI-CT study: a European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CT
Jérémie DabinNeige JournyTore S. IstadH. BayssonAusrele KesminieneMichael HauptmannMark S. PearceHilde Merete OlerudAste SovikRoman PokoraAmy Berrington De GonzalezKristina KjærheimIsabelle Thierry ChefPatrycja GradowskaArvid NordenskjöldArvid NordenskjöldMaria BlettnerRichard W HarbronMonika MoissonnierMagnus KaijserJohanna M. MeulepasMagda Bosch De BaseaElisabeth CardisLara StruelensMarie Odile BernierChristoffer JohansenLucian Le CornetLucian Le CornetLucian Le CornetDominique Lauriersubject
MaleOncologymedicine.medical_specialtyNeoplasms Radiation-InducedAdolescentEpidemiology[SDV]Life Sciences [q-bio]PediatricsRisk Assessment030218 nuclear medicine & medical imagingYoung Adult03 medical and health sciencesRadiation Protection0302 clinical medicineRisk FactorsRadiation IonizingInternal medicineEpidemiologymedicineHumansYoung adultChildCohort ProfilesRetrospective Studiesbusiness.industryInfant NewbornInfantCancerRetrospective cohort studyGeneral Medicinemedicine.disease3. Good healthEuropeEpidemiologic StudiesMulticenter studyChild Preschool030220 oncology & carcinogenesisCohortFemaleRadiation-induced cancerTomography X-Ray ComputedRisk assessmentbusinessdescription
International audience; •The multinational EPI-CT study was set-up in 2011 to provide direct estimates of risk of solid tumours and leukaemia among children and young adults who underwent computed tomography (CT) scanning and to consolidate the scientific basis for optimization of paediatric CT protocols and patient protection.•Under a common protocol, cohort studies were conducted in Belgium, Denmark, France, Germany, the Netherlands, Norway, Spain, Sweden and the United Kingdom, coordinated by the International Agency for Research on Cancer (IARC). •The study recruited a total of about 950,000 patients having undergone at least one CT-scan before the age of 22 years. A total of 8.7 million person-years of incidence follow-up were accrued between 1977 and 2014. Cohort members were followed up passively through linkage with population-based cancer and mortality registries. A methodology was developed to reconstruct individual organ doses and estimate associated uncertainties, using data available in electronic archiving systems of the radiology departments of participating hospitals. Description of the cohort and analysis of mortality risk are presented here.•Proposals for possible collaboration in further analyses of the data should be addressed to Dr. Ausrele Kesminiene (KesmienieneA@visitors.iarc.fr) and will be reviewed by the EPI-CT steering committee
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-02 | International Journal of Epidemiology |