Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

6533b82bfe1ef96bd128e302

RESEARCH PRODUCT

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

Mario F. Fraga Agustín F. Fernández Raúl F. Pérez Raúl F. Pérez Empar Lurbe Pablo Santamarina Pablo Santamarina Pau Redon Juan Ramón Tejedor Julio Alvarez Rocío G. Urdinguio

subject

Male 0301 basic medicine Aging ADN lcsh:Medicine General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Humans Longitudinal Studies Epigenetics Child Enhancer Genetics DNA methylation biology Genome Human Research lcsh:R Infant Newborn Reproducibility of Results General Medicine Methylation Epigenome Newborn Chromatin Chromatin 030104 developmental biology Histone CpG site Child Preschool 030220 oncology & carcinogenesis DNA methylation Longitudinal biology.protein CpG Islands Female Epigenetics Histone modification

description

[Background] Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes that occur during this period have not been sufficiently characterized in longitudinal studies.

year	journal	country	edition	language
2019-01-09	Journal of Translational Medicine

https://doi.org/10.1186/s12967-018-1751-9

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