6533b82cfe1ef96bd128edcf
RESEARCH PRODUCT
Cabut/dTIEG associates with the transcription factor Yorkie for growth control
Enrique BlancoMontserrat CorominasNuria ParicioMarina Ruiz-romeroFlorenci Serrassubject
Chromatin ImmunoprecipitationdTIEGgrowthBiologyProtein Serine-Threonine KinasesReal-Time Polymerase Chain ReactionBiochemistrybehavioral disciplines and activitiesModels BiologicalCabutRegulació genèticamental disordersGeneticsAnimalsDrosophila ProteinsDrosòfila -- GenèticaNuclear proteinYorkieMolecular BiologyGeneTranscription factorGeneticsSequence Analysis RNAfungiScientific ReportsGAFIntracellular Signaling Peptides and ProteinsNuclear ProteinsPromoterYAP-Signaling ProteinsPhenotypeCell biologyChromatinbody regionsJuvenile HormonesTrans-ActivatorsDrosophilaSignal transductionChromatin immunoprecipitationSignal TransductionTranscription Factorsdescription
The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-08 | EMBO Reports |