6533b82cfe1ef96bd128f63c

RESEARCH PRODUCT

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs.

Moritz GoslingRene RisselAlexander ZiebartAndreas Garcia-bardonErik K. HartmannRobert RuemmlerJens Kamuf

subject

medicine.medical_specialtyCardiac outputSwineGeneral Chemical EngineeringHemodynamicsBlood withdrawalShock HemorrhagicGeneral Biochemistry Genetics and Molecular BiologyMicrocirculation03 medical and health sciences0302 clinical medicine030202 anesthesiologyInternal medicinemedicineAnimalsOximetryCardiac OutputCerebral oximetry030304 developmental biology0303 health sciencesSpectroscopy Near-InfraredGeneral Immunology and Microbiologybusiness.industryGeneral NeuroscienceHemodynamic MonitoringHemodynamicsBrainReference StandardsOxygenShock (circulatory)Hemorrhagic shockCirculatory systemCardiologymedicine.symptombusiness

description

Hemorrhagic shock ranks among the main reasons for severe injury-related death. The loss of circulatory volume and oxygen carriers can lead to an insufficient oxygen supply and irreversible organ failure. The brain exerts only limited compensation capacities and is particularly at high risk of severe hypoxic damage.This article demonstrates the reproducible induction of life-threatening hemorrhagic shock in a porcine model by means of calculated blood withdrawal. We titrate shock induction guided by near-infrared spectroscopy and extended hemodynamic monitoring to display systemic circulatory failure, as well as cerebral microcirculatory oxygen depletion. In comparison to similar models that primarily focus on predefined removal volumes for shock induction, this approach highlights a titration by means of the resulting failure of macro- and microcirculation.

yearjournalcountryeditionlanguage
2019-05-21Journal of visualized experiments : JoVE
10.3791/59332https://pubmed.ncbi.nlm.nih.gov/31180364