6533b82cfe1ef96bd128f69c

RESEARCH PRODUCT

Treatment of cryptorchidism with a potent analog of gonadotropin-releasing hormone.

Jürgen BeyerAliza EshkolWolfgang CallenseeThomas WeberJohann August ErmertJoachim Happ

subject

Maleendocrine systemmedicine.medical_specialtyTime FactorsGonadotropin-releasing hormoneInternal medicineCryptorchidismMedicinePrecocious pubertyHumansChildbusiness.industryObstetrics and GynecologyInfantGnRH AnalogLuteinizing Hormonemedicine.diseaseGonadotropin secretionEndocrinologyReproductive MedicineChild PreschoolAntibody FormationOnce dailyFollicle Stimulating HormonebusinessPituitary Hormone-Releasing Hormoneshormones hormone substitutes and hormone antagonistsAfter treatmentGonadotropinsHormone

description

Pernasal therapy of cryptorchidism with D-Leu6-des-Gly10-gonadotropin-releasing hormone ethylamide (D-Leu6-des-Gly10-GnRH-EA), a potent, long-acting GnRH analog, was attempted. Eleven prepubertal cryptorchid boys received between 25 microgram once daily and 25 to 50 microgram twice daily for 5 to 12 weeks. Complete testicular descent was achieved in 4 of the 11 boys. GnRH tests (1.5 microgram/kg intravenously), conducted in six boys before treatment, after 4 weeks of treatment, and in 2 boys 3 months after treatment, did not reveal changes in gonadotropin secretion indicative of precocious puberty or of decreased hypophyseal sensitivity to GnRH. Antibodies to the GnRH analog or to GnRH could not be detected.

yearjournalcountryeditionlanguage
1978-05-01Fertility and sterility
10.1016/s0015-0282(16)43284-xhttps://pubmed.ncbi.nlm.nih.gov/27392