6533b82cfe1ef96bd1290100
RESEARCH PRODUCT
Use of the polymerase chain reaction to demonstrate hepatitis B virus DNA in serum of children with chronic hepatitis B.
Ulrike MöllersK. M. KellerAndreas WinterpachtStefan Wirthsubject
AdolescentHepatitis B virus DNA polymeraseHepatitis B virus DNAmedicine.disease_causePolymerase Chain ReactionVirusHepatitis B virus PRE betalaw.inventionChronic hepatitislawMedicineHumansHepatitis B e AntigensHepatitis B AntibodiesChildPolymerase chain reactionHepatitis B virusbiologybusiness.industryInfantbiology.organism_classificationHepatitis BVirologyHepadnaviridaeChild PreschoolPediatrics Perinatology and Child HealthChronic DiseaseDNA Viralbusinessdescription
The polymerase chain reaction was used to investigate the presence of hepatitis B virus DNA in sera of 61 children with chronic hepatitis B and negative results on dot biot hybridization tests. Our results demonstrate that most chronic carriers of hepatitis B surface antigen in childhood have hepatitis B virus DNA detectable by polymerase chain reaction in their serum and must be considered infectious.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 | The Journal of pediatrics |