6533b82dfe1ef96bd1291585

RESEARCH PRODUCT

Toll-like receptors: Expression and involvement in Multiple Myeloma

Gaëtan JegoGaëtan JegoCatherine Pellat-deuceunynckCatherine Pellat-deuceunynckDavid ChironDavid Chiron

subject

Cancer ResearchTLR9ApoptosisEndogenyHematologyBiologyLigandsmedicine.diseaseToll-Like Receptor 3Cell biologyGene Expression Regulation NeoplasticImmune systemOncologyApoptosisImmunityToll-Like Receptor 9TLR3medicineAnimalsHumansTumor EscapeMultiple MyelomaReceptorMultiple myeloma

description

Multiple Myeloma (MM) cells express and respond to a broad range of TLRs. Accumulating evidences suggest that TLRs act as double-edged sword in MM biology. Indeed, TLR9 or TLR3 ligands could enhance immunity against MM cells or directly induce cell apoptosis, whereas various TLR agonists could induce MM survival, proliferation, and immune escape. This review is focused on the heterogeneous expression and function of TLRs in MM and on the potential implication of TLR ligands of infectious or endogenous origin in MM emergence, resistance, or progression.

yearjournalcountryeditionlanguage
2010-04-11Leukemia Research
https://doi.org/10.1016/j.leukres.2010.06.002