6533b82efe1ef96bd12930bf
RESEARCH PRODUCT
Caffeate and piperidine-3-ol derivatives from the stem bark of Cassia sieberiana
Paul NayimVictor KueteBlanche Laure NdontsaPierre TaneRomeol Romain KoagneGabin Thierry M. BitchagnoGabin Thierry M. BitchagnoTill OpatzBrice C. K. AtontsaJames D. Simo MpetgaBrice E. N. WambaRoland T. Tchuenguemsubject
EthanolStigmasterolbiology010405 organic chemistryDPPHOrganic ChemistryPlant Sciencebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistrychemistry.chemical_compoundCassia sieberianachemistryPiperidineTroloxAntibacterial activityNuclear chemistryEC50description
A new caffeate derivative from the ethanol extract of the stem bark of Cassia sieberiana DC. is described herein along with the known secondary metabolites spectaline (2), iso-6-cassine (3), 3-O-methyl-chiro-inositol (4), monobehenin (5), octyl nonadecyloate (6), β-sitosterol (7), stigmasterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). The chemical structures were elucidated by means of various spectroscopic and spectrometric techniques. Extract and isolated compounds were devoid of inhibitory action against the herein selected bacterial strains (MICs > 256 μg/mL) but showed capacities to reduce 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (EC50 < 3 μg/mL) considerably better than the "gold standard" trolox (EC50 6.47 ± 0.48 μg/mL).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-01 | Natural Product Research |