6533b82efe1ef96bd1293ec3
RESEARCH PRODUCT
Methotrexate induced sprue-like syndrome
Juan Ramon CortsR AñónRosana VillagrasaEmpar MayordomoNelly BalzaAdolfo BenagesMarta M. BoscaCirilo Amorossubject
MalePathologymedicine.medical_specialtyDuodenummedicine.drug_classBiopsyProton-pump inhibitorCase ReportEndoscopy GastrointestinalSprueAtrophyBiopsymedicineHumansSpondylitis AnkylosingSpondylitisAnkylosing spondylitismedicine.diagnostic_testbusiness.industryGastroenterologySyndromeGeneral MedicineMiddle Agedmedicine.diseaseCeliac DiseaseMethotrexateIron-deficiency anemiaAntirheumatic AgentsMethotrexateAtrophybusinessmedicine.drugdescription
A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administrating intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-12-07 | World Journal of Gastroenterology |