6533b82ffe1ef96bd1295957

RESEARCH PRODUCT

DNA image cytometry in stomach carcinoma. Its relation to histomorphologic parameters and its influence on prognosis

A. GrenzHelmut E. GabbertThomas C. BöttgerC. JauckusT. C. StöckleTheo JungingerStefan Wellek

subject

Cancer ResearchPathologymedicine.medical_specialtyEpitheliomabusiness.industrySignet ring cellStomachmedicine.diseasemedicine.anatomical_structureOncologyCarcinomaMedicineAdenocarcinomabusinessStomach cancerLymph nodeDNA Image Cytometry

description

BACKGROUND The influence of DNA content on the prognosis in stomach cancer is controversial. METHOD After curative resection of stomach carcinomas (adenocarcinomas [n = 58]; signet ring cell carcinomas [n = 24]; undifferentiated carcinomas [n = 21]), the influence of the DNA content and histomorphologic parameters on the prognosis was examined. RESULTS In the multivariate regression analysis, the prognosis depended on the lymph node status (P = 0.0009), pT stage (P = 0.02), tumor localization (P = 0.03), and histologic type (P = 0.05). The prognosis was independent of the DNA content. Furthermore, the degree of differentiation, operative procedure, safety distance, size of the tumor, and sex and age of the patient also did not influence the prognosis. CONCLUSIONS The DNA content of the tumor cells in stomach carcinoma does not influence prognosis.

yearjournalcountryeditionlanguage
1992-10-01Cancer
https://doi.org/10.1002/1097-0142(19921001)70:7<1819::aid-cncr2820700702>3.0.co;2-o