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RESEARCH PRODUCT
Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study
Miguel-ángel Martínez-garcíaJosé-luis Cebrián-carreteroJosé-juan Pozo-kreilingerBlanca Del Carmen Migueláñez-medránAntonio-francisco López-sánchezsubject
MaleOncologymedicine.medical_specialtyoral cancer recurrenceMedicinaPilot ProjectsDiseaseRisk AssessmentMetastasis03 medical and health sciences0302 clinical medicineTongueInternal medicinemedicineCarcinomaHumansTongue NeoplasmGeneral DentistryNeoplasm StagingMouth neoplasmOral Medicine and Pathologybusiness.industryResearchCancer030206 dentistryoral cancer:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseTongue Neoplasmsoral squamous cell carcinomastomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologyUNESCO::CIENCIAS MÉDICAShistologic risk assessmentCarcinoma Squamous CellFemaleMouth NeoplasmsSurgeryNeoplasm Recurrence LocalbusinessRisk assessmentdescription
Background More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue. Classically, this disease has affected men preferentially, although recent studies suggest that trends are changing and the proportion of women with OSCC is increasing. In addition, the prevalence of oral cancer is also determined by some risk factors as alcohol consumption and tobacco. Currently, the Tumor, Node, Metastasis (TNM) classification is employed to defined tumor stage and based on this guide specific treatments are established. However, 5-year-survival does not exceed 50% of cases. The objective of this study is to determine whether a histological risk pattern indicative of higher recurrence might be present in T1-T2 tumors located in the anterior two thirds of the tongue. Material and Methods Samples from 26 patients with OSCC were analyzed and histological risk pattern of recurrent and non-recurrent tumors were compared. We have analyzed histological variables described in Anneroth and Brandwein-Gensler classifications. Additionally, we have also examined both clinical variables such as age, sex or comorbidities, as well as habits such as tobacco or alcohol consumption. Results We found that sex (male) and keratinization degree (high or moderate) are directly related with OSCC recurrence. In fact, free illness time is lower in men and higher in those cases with minimal or no keratinization. Conclusions Based on the variables analyzed, it has not been possible to establish a histological risk pattern that, complementary to the TNM classification, could have a predictive role in these early-stage tongue carcinomas. Key words:Oral cancer, oral squamous cell carcinoma, histologic risk assessment, oral cancer recurrence.
year | journal | country | edition | language |
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2019-01-28 | Medicina Oral Patología Oral y Cirugia Bucal |