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RESEARCH PRODUCT
Functional Adhesion of Pectin Biopolymers to the Lung Visceral Pleura
Andrew B. ServaisSteven J. MentzerAidan PierceYifan ZhengWilli L. WagnerWilli L. WagnerHassan A. KhalilZi ChenMaximilian Ackermannsubject
Pathologymedicine.medical_specialtyfood.ingredientPolymers and PlasticsPectinmedicine.medical_treatmentOrganic chemistryPectin bindingPaint adhesion testingArticleair leakslungGlycocalyxfoodQD241-441medicineCitrus PectinpectinLungChemistrydigestive oral and skin physiologyfood and beveragesGeneral ChemistryAdhesionrespiratory systemrespiratory tract diseasesChest tubeadhesionmedicine.anatomical_structurepleurapolysaccharidescanning electron microscopydescription
Pleural injuries and the associated “air leak” are the most common complications after pulmonary surgery. Air leaks are the primary reason for prolonged chest tube use and increased hospital length of stay. Pectin, a plant-derived heteropolysaccharide, has been shown to be an air-tight sealant of pulmonary air leaks. Here, we investigate the morphologic and mechanical properties of pectin adhesion to the visceral pleural surface of the lung. After the application of high-methoxyl citrus pectin films to the murine lung, we used scanning electron microscopy to demonstrate intimate binding to the lung surface. To quantitatively assess pectin adhesion to the pleural surface, we used a custom adhesion test with force, distance, and time recordings. These assays demonstrated that pectin–glycocalyceal tensile adhesive strength was greater than nanocellulose fiber films or pressure-sensitive adhesives (p <
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 | Polymers |