6533b830fe1ef96bd1296847
RESEARCH PRODUCT
Effects of acute exercise and allopurinol administration on soluble urokinase plasminogen activator receptor (suPAR).
Fabian Sanchis-gomarMa Carmen Gómez-cabreraHelios Pareja-galeanoJorge CandelGiuseppe LippiJose ViñaChiara Bonagurisubject
AdultMalemedicine.medical_specialtyacute exercise; allopurinol; suPARAllopurinolPhysical exerciseEnzyme-Linked Immunosorbent AssayallopurinolPlaceboSystemic inflammationacute exerciseGastroenterologyGeneral Biochemistry Genetics and Molecular BiologySuparnosticReceptors Urokinase Plasminogen ActivatorsuPARPlaceboschemistry.chemical_compoundInternal medicinemedicineHumansEnzyme InhibitorsXanthine oxidaseExerciseUrokinasebusiness.industrychemistrySuPARmedicine.symptombusinessmedicine.drugdescription
Background Although physical exercise acutely increases the most widely used inflammatory biomarkers, there is no information on its effect on soluble urokinase plasminogen activating receptor (suPAR), a circulating biomarker increasingly used for the assessment of systemic inflammation. Methods suPAR was assessed with the quantitative suPARnostic Standard ELISA Assay (Virogates, Birkerod, Denmark) in 12 professional football players before and after a football match. The athletes were divided into two experimental groups. An oral dose of 300 mg of allopurinol was administered to one group of six participants four hours before a match; the other six participants received placebo. Results Serum suPAR concentration did not vary significantly after the match in both the placebo and allopurinol group. No significant differences were observed between placebo and allopurinol groups at baseline and after the game. Conclusions At variance with other consolidated inflammatory biomarkers, suPAR is not influenced by either physical exercise or administration of xanthine oxidase inhibitors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-20 |