6533b830fe1ef96bd1297195

RESEARCH PRODUCT

Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register

Salvatore CorraoChristiano ArganoGiuseppe NatoliAlessandro NobiliGino Roberto CorazzaPier Mannuccio MannucciFrancesco PerticoneDomenico PriscoElena SilvestriGiacomo EmmiAlessandra BettiolCenci CaterinaGianni BioloMichela ZanettiMartina GuadagniMichele ZaccariMassimiliano ChiuchMichele ZaccariMassimo VanoliGiulia GrignaniEdoardo Alessandro PulixiMauro BernardiSilvia Li BassiLuca SantiGiacomo ZaccheriniGraziana LupattelliElmo MannarinoVanessa BianconiFrancesco PaciulloRiccardo AlcidiRanuccio NutiRoberto ValentiMartina RuvioSilvia CappelliAlberto PalazzuoliDomenico GirelliFabiana BustiGiacomo MarchiMario BarbagalloLigia DominguezFloriana CocitaVincenza BeneduceLidia PlancesSalvatore CorraoGiuseppe NatoliSalvatore MularoMassimo RaspantiFederica CavallaroMarco ZoliIlaria LazzariMattia BrunoriElisa FabbriDonatella MagalottiRaffaella ArnoFranco Laghi PasiniPier Leopoldo CapecchiGiuseppe PalascianoMaria Ester ModeoCarla Di GennaroMaria Domenica CappelliniDiletta MairaValeria Di StefanoGiovanna FabioSonia SeghezziMarta MancarellaMargherita Migone De AmicisGiacomo De LucaNatalia ScaramelliniMatteo CesariPaolo Dionigi RossiSarah DamantiMarta ClericiFederica ContiGiulia BoniniBarbara Brignolo OttoliniAntonio Di SabatinoEmanuela MiceliMarco Vincenzo LentiMartina PisatiCostanza Caccia DominioniGiovanni MurialdoAlessio MarraFederico CattaneoRoberto PontremoliValentina BeccatiGiulia NobiliMaria Beatrice SecchiDavide GhelfiLuigi AnastasioLucia SofiaMaria CarboneLuigi AnastasioLucia SofiaMaria CarboneFrancesco CipolloneMaria Teresa GuagnanoEmanuele ValerianiIlaria RossiGerardo MancusoDaniela CalipariMose BartoneGiuseppe DelitalaMaria BerriaChiara PesAlessandro DelitalaMaurizio MuscaritoliAlessio MolfinoEnrico PetrilloGiuseppe ZuccalaGabriella D'aurizioGiuseppe RomanelliAlessandra MarengoniAlberto ZucchelliFrancesca ManzoniAndrea VolpiniAntonio PicardiUmberto Vespasiani GentilucciPaolo GalloChiara Dell'untoGiorgio AnnoniMaurizio CorsiGiuseppe BellelliSara ZazzettaPaolo MazzolaHajnalka SzaboAlessandra BonfantiFranco ArturiElena SuccurroMariangela RubinoBruno TassoneGiorgio SestiMaria Grazia SerraMaria Antonietta BleveLaura GasbarroneMaria Rosaria SajevaAntonio BrucatoSilvia GhidoniFabrizio FabrisIrene BertozziGiulia BogoniMaria Victoria RabuiniElisabetta CosiPaolo ScarinziAnnalisa AmabileElisabetta OmenettoTancredi PrandiniRoberto ManfrediniFabio FabbianBenedetta BoariAlfredo De GiorgiRuana TiseoRoberto De GiorgioGiuseppe PaolissoMaria Rosaria RizzoClaudio BorghiEnrico StrocchiEugenia IannielloMario SoldatiCarlo SabbaFrancesco Saverio VellaPatrizia SuppressaPasquale AgostiAndrea SchilardiFrancesca LoparcoGiovanni Michele De VincenzoAlessio ComitangeloEmanuele AmorusoLuigi FenoglioAndrea FalcettaChristian BraccoAnna L. FracanzaniSilvia FargionSilvia TiraboschiAnnalisa CespiatiGiovanna ObertiGiordano SigonFlora PeyvandiRaffaella RossioBarbara FerrariGiulia ColomboValter MonzaniValeria SavojardoChristian FolliGiuliana CerianiFrancesco SalernoGiada PalliniFranco DallegriLuciano OttonelloLuca LiberaleLara CaserzaKassem SalamNicola Lucio LiberatoTiziana TogninGiovanni Battista BianchiSabrina GiaquintoFrancesco PurrelloAntonino Di PinoSalvatore PiroRenzo RozziniLina FalangaElena SpazziniCamillo FerrandinaGiuseppe MontrucchioPaolo PetittiPaolo PeassoEdoardo FavaleCesare PolettoRaffaella SalmiPiergiorgio GaudenziFrancesco VioliLudovica PerriRaffaele LandolfiMassimo MontaltoAntonio MirijelloLuigina GuastiLuana CastiglioniAndrea MarescaAlessandro SquizzatoLeonardo CampiottiAlessandra GrossiMarco BertolottiChiara MussiGiulia LancellottiMaria Vittoria LibbraGiulia DondiElisa PellegriniLucia CarulliMatteo GalassiYasmine GrassiFrancesco PerticoneMaria PerticoneRosa BattagliaMarco FiliceRaffaele MaioVincenzo StanghelliniEugenio RuggeriSara Del VecchioAndrea SalviRoberto LeonardiGiampaolo DamianiWilliam CapeciArmando GabrielliMassimo MattioliGiuseppe Pio MartinoLorenzo BiondiPietro PettinariRiccardo GhioAnna Dal ColSalvatore MinisolaLuciano ColangeloMirella CilliGiancarlo LabbadiaAntonella AfeltraBenedetta MariglianoMaria Elena PipitaPietro CastellinoLuca ZanoliSamuele PignataroAlfio GennaroJulien BlancoValter SaraccoMarisa FogliatiCarlo BussolinoFrancesca MeteMiriam GinoAntonio CittadiniCarlo VigoritoMichele ArcopintoAndrea SalzanoEmanuele BobbioAlberto Maria MarraDomenico SiricoGuido MoreoFrancesca GaspariniSilvia ProloGloria PinaAlberto BallestreroFabio FerrandoSergio BerraSimonetta DassiMaria Cristina NavaBruno GraziellaStefano BaldassarreSalvatore FragapaniGabriella GrudenGiorgio GalantiGabriele MascheriniCristian PetriLaura StefaniMargherita GirinoValeria PiccinelliFrancesco NassoVincenza GioffreMaria PasqualeGiuseppe ScattolinSergio MartinelliMauro TurrinLeonardo SechiCristina CatenaGianluca ColussiNicola PassarielloLuca RinaldiFranco BertiGiuseppe FamularoPatrizia TarsitaniRoberto CastelloMichela PasinoGian Paolo CedaMarcello Giuseppe MaggioSimonetta MorgantiAndrea ArtoniStefano Del GiaccoDavide FirinuFrancesca LosaGiovanni PaolettiGiulia CostanzoGiuseppe MontaltoAnna LicataValentina MalerbaFilippo Alessandro MontaltoAntonino LascoGiorgio BasileAntonino CatalanoLorenzo MalatinoBenedetta StancanelliValentina TerranovaSalvatore Di MarcaRosario Di QuattroLara La MalfaRossella CarusoPatrizia MecocciCarmelinda RuggieroVirginia BoccardiTiziana MeschiFulvio LauretaniAndrea TicinesiAntonio NouvennePietro MinuzLuigi FondrieschiMario PirisiGian Paolo FraDaniele SolaMassimo PortaPiero RivaRoberto QuadriErica LarovereMarco NovelliGiorgio ScanziCaterina MengoliStella ProviniLaura RicevutiEmilio SimeoneRosa ScurtiFabio TollosoRoberto TarquiniAlice ValorianiSilvia DolentiGiulia VanniniAlberto TedeschiLucia TrottaRiccardo VolpiPietro BocchiAlessandro VignaliSergio HarariChiara LonatiMara CattaneoFederico Napoli

subject

medicine.medical_specialtyMultivariate analysislcsh:MedicineSocio-culturaleDisease030204 cardiovascular system & hematologyelderlyArticleCoronary artery disease03 medical and health sciences0302 clinical medicineInternal medicineMedicine030212 general & internal medicineDepression (differential diagnoses)Polypharmacybusiness.industrylcsh:RGeneral Medicinemedicine.diseaseComorbidityelderly sex profiles disease distribution in-hospital mortality 3-month mortality 1-year mortalityMood disordersdisease distribution1-year mortality3-month mortalitysex profilesbusiness1-year mortality; 3-month mortality; disease distribution; elderly; in-hospital mortality; sex profilesKidney diseasein-hospital mortality

description

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients. Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Results: Among 4714 patients, 51% were women and 49% were men. The disease distribution showed that diabetes, coronary artery disease, chronic obstructive pulmonary disease, chronic kidney disease, and malignancy were more frequent in men but that hypertension, anaemia, osteoarthritis, depression, and diverticulitis disease were more common in women. Severity and comorbidity indexes according to the Cumulative Illness Rating Scale (CIRS-s and CIRS-c) were higher in men, while cognitive impairment, mood disorders, and disability in daily life measured by the Barthel Index (BI) were worse in women. In the multivariate analysis, BI, CIRS, and malignancy significantly increased the risk of death in men at the 1-year follow-up, while age was independently associated with mortality in women. Conclusions: Our study highlighted the relevance and the validity of our previous predictive model in the identification of sex dimorphism in hospitalised elderly patients underscoring the need of sex-personalised health-care.

yearjournalcountryeditionlanguage
2019-01-12
10.3390/jcm8010081http://hdl.handle.net/11591/442485