6533b830fe1ef96bd12978af

RESEARCH PRODUCT

Isolation of Alkaloids from Cultured Hybrid Cells of Rauwolfia serpentina*Rhazya stricta.

Susanne EndrebJoachim StöckigtWataru NittaNaoko OyaNorio AimiIgor KostenyukShin-ichiro SakaiHiromitsu TakayamaYuri GlebaMariko Kitajima

subject

chemistry.chemical_classificationIndole alkaloidbiologyApocynaceaeChemistryAlkaloidMonoterpeneGlycosideGeneral ChemistryGeneral MedicinePharmacognosyRhazya strictabiology.organism_classificationCell cultureDrug DiscoveryBotanyheterocyclic compounds

description

Two monoterpenoid indole alkaloids and four β-carbolines were isolated from a hydrid cell suspension culture generated from two Apocynaceous plants, Rauwolfia serpentina Benth. and Rhazya stricta Decaisne. This indicates that the function of alkoloid biosynthesis is retained after hybrid formation and that alkaloids not previously detected in the parental plants or cell cultures are formed.

https://doi.org/10.1248/cpb.44.1637