6533b831fe1ef96bd129843c
RESEARCH PRODUCT
Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis
Maria Sole ChimentiRaffaele ScarpaSerena VettoriMonica TodoertiPier Luigi MeroniSalvatore De VitaGianluca MoronciniSalvatore Di BartolomeoAlessandra BortoluzziDomenico Paolo Emanuele MargiottaE Bartoloni-bocciBenjamin A FisherEugen FeistFrancesco UrsiniRoberto CaporaliFrancesco CasoGuido ValesiniRoberto GiacomelliOnorina BerardicurtiMarcella PreteEmmanuel ColomaPaola CiprianiRicard CerveraFederico PerosaRoberta PrioriVasiliki LiakouliMaria GerosaAndrea DoriaChiara RebuffiAthanasios G. TzioufasAntonella AfeltraAlessia AlunnoClaudio VitaliGiuliana GugginoOliver DistlerSalvatore D'angeloMichele GilioYehuda ShoenfeldMichele BombardieriFabrizio ContiPiero Ruscittisubject
0301 basic medicineEvidence-based practiceImmunologyInflammationGuidelines as TopicSystemic lupus erythematosuBioinformaticsAntiphospholipid syndrome; Biomarker; Rheumatoid arthritis; Sjögren syndrome; Spondyloarthritides; Systemic lupus erythematosus; Systemic sclerosis;Autoimmune DiseaseAutoimmune DiseasesRheumatic Disease03 medical and health sciencesTherapeutic approachSystemic sclerosiEconomica0302 clinical medicineImmune systemSystemic lupus erythematosusAntiphospholipid syndromeEarly DiagnosiRheumatic DiseasesAntiphospholipid syndromemedicineImmunology and AllergyHumansRheumatoid arthritisRheumatoid arthritiAntiphospholipid syndrome; Biomarker; Rheumatoid arthritis; Sjögren syndrome; Spondyloarthritides; Systemic lupus erythematosus; Systemic sclerosis030203 arthritis & rheumatologySpondyloarthritidebusiness.industryBiomarkermedicine.diseaseClinical diseaseSjögren syndromeAntiphospholipid syndrome; Biomarker; Rheumatoid arthritis; Sjögren syndrome; Spondyloarthritides; Systemic lupus erythematosus; Systemic sclerosis; Autoimmune Diseases; Biomarkers; Early Diagnosis; Evidence-Based Practice; Guidelines as Topic; Humans; Rheumatic Diseases; Immunology and Allergy; ImmunologySettore MED/16 - Reumatologia030104 developmental biologyEarly DiagnosisRheumatoid arthritisEvidence-Based PracticeBiomarker (medicine)SpondyloarthritidesSystemic sclerosismedicine.symptombusinessBiomarkersHumandescription
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest. A biomarker generally refers to a measured characteristic which may be used as an indicator of some biological state or condition. Three different types of medical biomarkers has been suggested: i. mechanistic markers; ii. clinical disease markers; iii. therapeutic markers. A combination of biomarkers from these different groups could be used for an ideal more accurate diagnosis and treatment. However, although a growing body of evidence is focused on improving biomarkers, a significant amount of this information is not integrated on standard clinical care. The overarching aim of this work was to clarify the meaning of specific biomarkers during autoimmune diseases; their possible role in confirming diagnosis, predicting outcome and suggesting specific treatments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-08-06 |