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RESEARCH PRODUCT
Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Bahijja Tolulope Raimi-abrahamMaria De Fátima PinaAlison Veronica KeatingLaura Modica De MohacLaura Modica De Mohacsubject
Materials scienceamorphousoral drug deliveryPharmaceutical Sciencelcsh:RS1-44102 engineering and technologyReview030226 pharmacology & pharmacylcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineamorphoucrystallineaqueous solubility enhancementDissolutionelectrospinningsolid dispersion021001 nanoscience & nanotechnologyElectrospinningAmorphous solidSynthetic fiberChemical engineeringPARTICLE SIZE REDUCTION0210 nano-technologyDispersion (chemistry)Oral retinoidSalt formationdescription
Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |