6533b832fe1ef96bd129a34e
RESEARCH PRODUCT
Retroespalhamento luminoso das córneas de pacientes com diabete melito dependente e não dependente de insulina: estudo piloto
Santiago García-lázaroRafael J. Pérez-cambrodíJosé J. Esteve-taboadaAna M. Calvo-marotoAlejandro Cerviñosubject
MaleVisual acuityCorneal Pachymetrygenetic structuresScheimpflug principleVisual AcuityPilot ProjectsDiagnostic Techniques OphthalmologicalCorneal DiseasesCornea0302 clinical medicineDiabetes mellituslcsh:OphthalmologyReference ValuesCorneaMedicineCorneal pachymetrymedicine.diagnostic_testCorneal DiseasesAge FactorsScheimpflug imagingGeneral MedicineMiddle AgedCorneal topographymedicine.anatomical_structureDiabetes mellitus tipo 2Diabetes mellitus tipo 1Femalemedicine.symptomAdultmedicine.medical_specialtyProjetos pilotoStatistics Nonparametric03 medical and health sciencesAnterior Eye SegmentDiabetes mellitusOphthalmologyHumansScheimpflug Topografia da córneaAgedbusiness.industryCase-control studyReproducibility of ResultsDiabetes mellitus type 1Diabetes mellitus type 2medicine.diseaseeye diseasesOphthalmologyPilot projectDiabetes Mellitus Type 1Diabetes Mellitus Type 2lcsh:RE1-994Case-Control Studies030221 ophthalmology & optometrysense organsCorneal topographybusiness030217 neurology & neurosurgerydescription
ABSTRACT Purpose: To compare central corneal backscatter obtained from Scheimpflug images between patients with insulin-dependent and non-insulin-dependent diabetes mellitus (IDDM and NIDDM, respectively) and healthy controls. Methods: Seven patients with IDDM (7 eyes), eleven patients with NIDDM (11 eyes), and sixteen healthy subjects (16 eyes) were included in this pilot study. Scheimpflug imaging system (Pentacam, Oculus Inc., Germany) was used to obtain optical sections of the cornea. Seven meridians were analyzed for each eye, oriented from 70° to 110°. Optical density values for the central 3-mm and 5-mm zones of the cornea were obtained by image analysis using external software. Results: Corneal backscatter was significantly higher in the diabetic patients than in the controls for the central 3-mm (p=0.016) and 5-mm (p=0.014) zones. No significant differences in corneal backscatter were found between the IDDM and NIDDM groups for either zone (both p>0.05). In the NIDDM group, significant correlations were observed for both central zones between corneal backscatter and age (3 mm: r=0.604, p=0.025; 5 mm: r=0.614, p=0.022) and central corneal thickness (3 mm: r=0.641, p=0.017; 5 mm: r=0.671, p=0.012); this was not found in the IDDM group (p>0.05). The presence of diabetes showed a significant effect on central corneal backscatter (Kruskal-Wallis test, p0,05 em ambos os casos). No grupo NIDDM, observaram-se correlações significativas para as zonas centrais de 3 mm e 5 mm, entre retroespalhamento luminoso corneano e idade (r=0,604 p=0,025 e r=0,614 p=0,022, respectivamente) e espessura central corneana (r=0,641 p=0,017; r=0,671 p=0,012, respectivamente), o que não foi encontrado no grupo IDDM (p>0,05). O teste de Kruskall-Wallis indicou que a presença de diabete tem um efeito significativo sobre a retroespalhamento central da córnea (p<0,001). Conclusões: Pacientes diabéticos apresentaram valores mais elevados de retroespalhamento luminoso corneano do que indivíduos saudáveis. A análise da densidade óptica corneana pode ser uma ferramenta útil para monitorar e avaliar as alterações oculares causadas pela diabete.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-01 |