6533b833fe1ef96bd129b844

RESEARCH PRODUCT

Immunohistochemistry of primary central nervous system malignant rhabdoid tumors: report of five cases and review of the literature

Wolfgang BrückHans A. KretzschmarArnulf PekrunJulianne BehnkeHans H. GoebelHans-jürgen ChristenBettina Behring

subject

Central Nervous SystemMalePathologymedicine.medical_specialtyNeurofilamentCentral nervous systemVimentinHistogenesisBiologyPathology and Forensic MedicineCentral nervous system disease03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicinemedicineHumansRhabdoid TumorHyalineBrain NeoplasmsRhabdoid tumorsInfantmedicine.diseaseImmunohistochemistry3. Good healthMicroscopy Electronmedicine.anatomical_structureChild Preschool030220 oncology & carcinogenesisbiology.proteinImmunohistochemistryFemaleNeurology (clinical)030217 neurology & neurosurgery

description

Malignant rhabdoid tumors (MRT) are characterized by a typical light microscopic morphology with uniformly round tumor cells, vacuolated cytoplasm with occasional round, hyaline intracytoplasmic, periodic acid-Schiff-positive inclusions, vesicular nuclei with prominent nucleoli and positive immunoreactivity for vimentin. The histogenesis of MRT is controversial. Five cases of primary central nervous system (CNS) rhabdoid tumors in children are presented. Immunohistochemical, light and electron microscopic features are compared with primary CNS malignant rhabdoid tumors reported in the literature. Expression of various neurofilaments in our cases of primary CNS rhabdoid tumors was prominent and we therefore favor a neural differentiation of extrarenal intracerebral rhabdoid tumors.

yearjournalcountryeditionlanguage
1996-05-23Acta Neuropathologica
https://doi.org/10.1007/s004010050470