6533b833fe1ef96bd129b85a

RESEARCH PRODUCT

Optical Coherence Tomography Angiography of Macula and Optic Nerve in Autism Spectrum Disorder: A Pilot Study

Dolores Parraga-muñozMaria D Pinazo-duranMaria D Pinazo-duranJose Javier Garcia-medinaAlfonso Perez-martinezMonica Del-rio-vellosilloElena Rubio-velazquezMaria Dolores Lopez-bernal

subject

medicine.medical_specialtygenetic structuresNerve fiber layerlcsh:Medicineautism spectrum disorderoptical coherence tomography angiographyArticleoptic nerveperfusion03 medical and health scienceschemistry.chemical_compound0302 clinical medicineOptical coherence tomographyOphthalmologyvessel densitymedicinemacula030304 developmental biology0303 health sciencesRetinamedicine.diagnostic_testbusiness.industrylcsh:RautoregulationRetinalneurotypicalGeneral MedicineDiabetic retinopathymedicine.diseaseeye diseasesthicknessfluxmedicine.anatomical_structurechemistryAutism spectrum disorderOptic nervesense organsbusinessPerfusion030217 neurology & neurosurgery

description

The aim of this study was to compare retinal thicknesses and vascular parameters between autism spectrum disorder (ASD) and neurotypical (NT) individuals. Recruited ASD subjects and age- and sex-matched NT controls underwent 2 optical coherence tomography scans (OCT) (macular cube and optic nerve cube) and 2 OCT angiography (OCTA) scans (macular and optic nerve head (ONH) OCTA) with the device Cirrus 5000 (Zeiss). Concerning OCT, we considered full retina thickness in 9 macular sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) pattern and peripapillary retinal nerve fiber layer (pRNFL) thickness in 4 quadrants and 12 clock-hour sectors. Vessel density and capillary perfusion density in 9 sectors were measured using 6 &times

yearjournalcountryeditionlanguage
2020-09-27Journal of Clinical Medicine
10.3390/jcm9103123http://dx.doi.org/10.3390/jcm9103123