6533b833fe1ef96bd129c2bb

RESEARCH PRODUCT

Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful?

Natale D'alessandroPaola PomaGiuseppe Montalto

subject

DrugCarcinoma HepatocellularHepatocellular carcinomamedia_common.quotation_subjectDrug transporterDrug resistancePharmacologyBiologyMalignancyNF-κBInhibitor of Apoptosis ProteinsPlant polyphenolsPhenolsmedicineHumansInhibition of cell deathTopic HighlightsTranscription factorSensitizationmedia_commonFlavonoidsLiver NeoplasmsNF-kappa BGastroenterologyPolyphenolsGeneral MedicineIAPmedicine.diseaseNFKB1medicine.anatomical_structureDrug Resistance NeoplasmApoptosisDrug resistanceHepatocellular carcinomaCancer researchPlant PreparationsPhytotherapy

description

Primary hepatocellular carcinoma (HCC) is a quite frequent tumor which results in high mortality and most often exhibits a poor response to present drug therapies. Clearly, a thorough understanding of the biological bases of this malignancy might suggest new strategies for its treatment. Here we examine the evidences that both "pharmacological" mechanisms (e.g. drug transporter or detoxification enzyme over-expression) and alterations in other critical factors, including the IAPs (Inhibitory of Apoptosis Proteins), involved in enhancement of cell survival and proliferation may determine the therapeutic resistance of HCC; we also underline the possible role in the process of the activation of transcription factors, like NF-kappaB, capable of contemporaneously up-regulating the mechanisms discussed. On this basis, we finally comment on the possible use of natural multi-targeted antitumoral agents like plant polyphenols to achieve sensitization to treatments in HCC.

https://doi.org/10.3748/wjg.v13.i14.2037