6533b834fe1ef96bd129e14c

RESEARCH PRODUCT

Methodological Aspects of the Application of the Naka-Rushton Equation to Clinical Electroretinogram

R GeracitanoM. LauricellaM AnastasiM Brai

subject

AdultMaleX ChromosomeAdolescentLightElectrodiagnosisGenetic LinkageVisual AcuityDark AdaptationCataractRetinaCellular and Molecular NeuroscienceExperimental LaboratoriesOpticsRetinal DiseasesElectroretinographymedicineHumansResponse AmplitudeApplied mathematicsScotopic visionChildAgedMathematicsmedicine.diagnostic_testbusiness.industryDerivative analysisGeneral MedicineMiddle AgedSensory SystemsOphthalmologyFemalebusinessRetinitis PigmentosaElectroretinography

description

The nonlinear relation between stimulus intensity and response amplitude of the electroretinogram (ERG) scotopic b wave can be described by a curve based on the Naka-Rushton (NR) equation. Up to now, the NR equation has been used to assess the features of the normal and pathological ERG, but the best approach for a correct evaluation of the parameters is still debatable. The parameters are thought to be related to the different conditions of retinal activities. The method is well known in experimental laboratories but is quite unusual at the clinical level. In the present paper the derivative analysis of the NR function is proposed as an easier approach to understand the variations of the NR parameters in selected pathologies.

yearjournalcountryeditionlanguage
1993-01-01Ophthalmic Research
https://doi.org/10.1159/000267283