6533b835fe1ef96bd129f501

RESEARCH PRODUCT

Switching on the deep brain stimulation: effects on cardiovascular regulation and respiration.

Giorgio BarlettaGiovanna Calandra-buonauraPietro GuaraldiPietro CortelliRossana TerlizziSimone VigneriAnnagrazia Cecere

subject

AdultMalemedicine.medical_specialtyDeep brain stimulationSupine positionRespiratory ratemedicine.medical_treatmentDeep Brain StimulationStimulationCluster HeadacheCardiovascularCardiovascular Physiological PhenomenaCellular and Molecular NeuroscienceCardiovascular Deep brain stimulation Blood pressure Heart rate Respiratory Parkinson ClusterInternal medicineHeart rateMedicineHumansParkinsonRespiratory systemAgedHEART RATEEndocrine and Autonomic Systemsbusiness.industryCluster headacheParkinson DiseaseMiddle Agedmedicine.diseaseElectrodes ImplantedBlood pressureClusterAnesthesiaBlood pressureRespiratoryCardiologyRespiratory Physiological PhenomenaFemaleNeurology (clinical)businessFollow-Up Studies

description

Abstract Background Objective of this study was to evaluate the acute cardiovascular and respiratory effects of switching on the deep brain stimulation in the follow up of nine Parkinson's disease patients with subthalamic nucleus stimulation and six cluster headache patients with posterior hypothalamic area stimulation. Methods Systolic and diastolic blood pressure, heart rate, and respiratory rate were monitored continuously during supine rest in both groups. Each patient was assessed in two conditions: resting supine with stimulator off and with stimulator on. Results In supine resting condition switching on the DBS induced no significant changes ( p  > 0.05) in systolic and diastolic blood pressure as well as in heart rate and respiratory rate, in both groups of patients, either taking 1 min or 10 heartbeats as a sample for analysis. Conclusions Switching on the DBS does not modify heart rate, blood pressure nor respiratory rate in both Parkinson and cluster headache patients under resting conditions.

yearjournalcountryeditionlanguage
2011-05-11Autonomic neuroscience : basicclinical
10.1016/j.autneu.2011.09.002https://pubmed.ncbi.nlm.nih.gov/21978795