6533b835fe1ef96bd129f72b
RESEARCH PRODUCT
Peptide metal-organic frameworks under pressure: flexible linkers for cooperative compression
Ismael Mullor-ruízIsmael Mullor-ruízAlfredo SeguraDaniel ErrandoneaCarlos Marti-gastaldoJosé Navarro-sánchezJavier González-platasDavid Santamaría-pérezCatalin Popescusubject
chemistry.chemical_classificationDipeptideCoordination sphereSupramolecular chemistryQuímica organometàl·licaPeptideSequence (biology)02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences0104 chemical sciencesInorganic ChemistryCrystallographychemistry.chemical_compoundchemistrySide chainMetal-organic frameworkPèptids0210 nano-technologyLinkerdescription
We investigate the structural response of a dense peptide metal-organic framework using in situ powder and single-crystal X-ray diffraction under high-pressures. Crystals of Zn(GlyTyr)2 show a reversible compression by 13% in volume at 4 GPa that is facilitated by the ability of the peptidic linker to act as a flexible string for a cooperative response of the structure to strain. This structural transformation is controlled by changes to the conformation of the peptide, which enables a bond rearrangement in the coordination sphere of the metal and changes to the strength and directionality of the supramolecular interactions specific to the side chain groups in the dipeptide sequence. Compared to other structural transformations in Zn(ii) peptide MOFs, this behaviour is not affected by host/guest interactions and relies exclusively on the conformational flexibility of the peptide and its side chain chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-06-01 |