6533b836fe1ef96bd12a09e6
RESEARCH PRODUCT
Cholestasis in newborn infants with perinatal asphyxia
Mario GiuffrèA StagniE. GenoveseM DecurtisR PaludettoPietro VajroA Ameliosubject
Malemedicine.medical_specialtyCholestasis IntrahepaticInfant Premature DiseasesGastroenterologyLiver Function TestsCholestasisInternal medicinemedicineHumansNeonatal cholestasisAsphyxiaAsphyxia Neonatorummedicine.diagnostic_testbusiness.industryInfant NewbornGeneral Medicinemedicine.diseasePerinatal asphyxiaNeonatal hepatitisNeonatal cholestasisPerinatal asphyxiaEndocrinologyLiverLiver biopsyPediatrics Perinatology and Child HealthAbnormal Liver Function TestFemalemedicine.symptomLiver function testsbusinessInfant Prematuredescription
Objective: The aim of this study was to characterize the liver involvement in infants who have both neonatal asphyxia and neonatal cholestasis. Methods: We describe four asphyctic newborn infants (three born at term) who developed early (age 3.8 ± 2.1 days) intrahepatic neonatal cholestasis and in whom tests for causes of neonatal liver damage were negative. Results: The clinical picture and course were benign and similar to that of sporadic 'idiopathic' neonatal hepatitis. Clinical signs and abnormal liver function tests tended to normalize within the first year of life in all. Conjugated bilirubin became normal at 6 months after the onset of cholestasis, while liver enzymes tended towards normal values thereafter, within 1 year of follow-up. Liver biopsy (taken in one patient) showed a typical picture of giant cell hepatitis; ultrastructure was non-specific. Significance: Our results suggest that isolated asphyxia should be taken into account as a potential causal factor in term or pre-term asphyctic newborns who develop early 'idiopathic' neonatal cholestasis.
year | journal | country | edition | language |
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1997-01-01 |