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RESEARCH PRODUCT
Craniomaxillofacial morphology alterations in children, adolescents and adults with neurofibromatosis 1 : a cone beam computed tomography analysis of a Brazilian sample
Karin Soares Gonçalves CunhaAlexandre-trindade MottaFlávia LimaMauro GellerMaria-elisa-rangel JaniniRaquel-richelieu-de Andrade PontesLicínio Esmeraldo Da SilvaFábio-ribeiro GuedesEloá-borges Lunasubject
Cephalometric analysisAdultMaleCone beam computed tomographycongenital hereditary and neonatal diseases and abnormalitiesNeurofibromatosis 1AdolescentCephalometry03 medical and health sciencesYoung Adult0302 clinical medicinestomatognathic systemmedicineHumansProspective StudiesNeurofibromatosisChildGeneral DentistryneoplasmsAgedAnamnesisOrthodonticsSkull BaseOral Medicine and Pathologybusiness.industryResearchMandible030206 dentistryCone-Beam Computed TomographyMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseasenervous system diseasesSkullstomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologyJawMaxillaCase-Control StudiesChild PreschoolUNESCO::CIENCIAS MÉDICASEarly adolescentsSurgeryFemalebusiness030217 neurology & neurosurgeryBrazildescription
Background Oral manifestations are common in neurofibromatosis 1 (NF1), and include jaws and teeth alterations. Our aim was to investigate the craniomaxillofacial morphology of Brazilian children, adolescents and adults with NF1 using cone beam computed tomography. Material and Methods This study was conducted with 36 Brazilian individuals with NF1 with ages ranging from 4 to 75. The participants were submitted to anamnesis, extra and intraoral exam and cephalometric analysis using cone beam computed tomography. Height of the NF1 individuals was compared to the length of jaws and skull base. The results of the cephalometric measurements of the NF1 group were compared with a control group paired by age, gender and skin color. Results Individuals with NF1 had lower maxillary length (p<0.0001), lower mandibular length (p<0.0001), lower skull base length (p<0.0001). In children and adolescents, the mandible was more posteriorly positioned (p=0.01), when compared with the control group. There was no association between jaws and skull base length with the height of the individuals with NF1. Conclusions Brazilian children, adolescents and adults with NF1 have short mandible, maxilla and skull base. Moreover, children and adolescents present mandibular retrusion. Key words:Neurofibromatosis 1, oral manifestations, craniofacial abnormalities, cone beam computed tomography.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-05 |