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RESEARCH PRODUCT
Inhibition of Fcγ Receptors in the Plasma of Subjects with Down's Syndrome
Claudio RossiGabriella GuarnottaE GiardinaDonatella CasigliaGiovani TrioloA Accardo-palumbosubject
AdultDown syndromeErythrocytesRosette FormationAdolescentImmunologyDNA Single-StrandedAntigen-Antibody ComplexAntibodiesPolyethylene GlycolsPathology and Forensic MedicinePathogenesisImmune systemmedicineAnimalsChemical PrecipitationHumansImmunology and AllergyLymphocytesChildReceptorbiologyRosette (schizont appearance)Receptors IgGAutoantibodyInfantmedicine.diseaseImmunoglobulin AImmunoglobulin MChild PreschoolImmunoglobulin GImmunologybiology.proteinDown SyndromeAntibodyTrisomyChickensdescription
Abstract Subjects with Down's syndrome have several immunological abnormalities. We examined the sera of 29 subjects with Down's syndrome for the presence of Fcγ receptor blocking and for the presence of anti-ssDNA antibodies by EA rosette inhibition. Fifty-five percent of Down subjects had levels of inhibition above the upper limit of normality in comparison to 7% of normal controls. The finding that after polyethylene glycol precipitation of selected sera giving high levels of EA rosette inhibition there was a reduction or a disappearance of the EA rosette inhibition could indicate that the blocking factors detected behaved as immune complexes. Since almost all subjects with anti-ssDNA antibodies also had elevated values of EA rosette inhibition, a role for immune complexes eventually formed with autoantibodies in an Fc-mediated immunoregulatory system is suggested.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-10-01 | Clinical Immunology and Immunopathology |