6533b837fe1ef96bd12a33d5

RESEARCH PRODUCT

Transcranial magnetic resonance-guided focused ultrasound thalamotomy as a safe treatment option in multiple sclerosis patients with essential tremor

Cesare GagliardoMassimo MidiriGiuseppe SalemiPaolo RagoneseMarco D'amelioGerardo Iacopino

subject

medicine.medical_specialtyNeurologyMovement disordersMagnetic Resonance SpectroscopyMultiple Sclerosismedicine.medical_treatmentEssential TremorDermatologyStereotaxic Techniques03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationThalamusMultiple SclerosimedicineHumansInterventional Magnetic Resonance Imaging030212 general & internal medicineExpanded Disability Status Scalemedicine.diagnostic_testEssential tremorThalamotomybusiness.industrySettore MED/27 - NeurochirurgiaMultiple sclerosisSettore MED/37 - NeuroradiologiaMagnetic resonance imagingGeneral Medicinemedicine.diseaseMagnetic Resonance Imagingnervous system diseasesPsychiatry and Mental healthTreatment OutcomeStereotaxic techniqueHigh-Intensity Focused Ultrasound AblationSettore MED/26 - NeurologiaNeurology (clinical)medicine.symptombusinessSettore MED/36 - Diagnostica Per Immagini E Radioterapia030217 neurology & neurosurgery

description

Transcranial magnetic resonance-guided focused ultrasound is a recently introduced incisionless treating option for essential tremor and tremor-dominant idiopathic Parkinson disease. There is preliminary evidence that it may result in a promising effective treatment option for other movement disorders too. Here, we report on two patients with multiple sclerosis with medication refractory debilitating essential tremor comorbidity who successfully underwent unilateral Vim tcMRgFUS thalamotomy for tremor control. Patients' clinical condition and expanded disability status scale scores showed no changes during the 1-year follow-up period with no evidence of multiple sclerosis activity or progression.

10.1007/s10072-020-04841-4http://hdl.handle.net/10447/437318