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RESEARCH PRODUCT

Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population

Paula CarrascoFrancisco Felipe ChavesConcha CerdáAntonio IradiMaría Isabel CovasMarta FandosRosa M. Lamuela-raventósM. Carmen TormosGuillermo-t. SáezMiguel ÁNgel Martínez-gonzálezRafael TorregrosaDolores OceteRedon JosepDolores CorellaRamon EstruchOlga PortolésMarisa GuillénMaria Teresa Michavilla

subject

Malemedicine.medical_specialtyAntioxidantmedicine.medical_treatmentPopulationmedicine.disease_causeBiochemistrySuperoxide dismutasechemistry.chemical_compoundSex FactorsRisk FactorsInternal medicineDiabetes mellitusmedicineHumanseducationAgedAged 80 and overchemistry.chemical_classificationeducation.field_of_studybiologyGlutathione peroxidaseAge FactorsGeneral MedicineGlutathioneMiddle AgedMalondialdehydemedicine.diseaseOxidative StressEndocrinologychemistryBiochemistryCardiovascular DiseasesSpainbiology.proteinFemaleOxidative stressDNA Damage

description

The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7′8′-dihydro-2′-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were signifi cantly higher while catalase and glutathione peroxidase activities were signifi cantly lower in high cardiovascular risk participants than in controls. Statistically signifi cant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.

yearjournalcountryeditionlanguage
2009-11-13Free Radical Research
https://doi.org/10.3109/10715760903247231