Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer

6533b838fe1ef96bd12a46d3

RESEARCH PRODUCT

Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer

Valentina Gambardella Susana Roselló Andrés Cervantes Juan Miguel Cejalvo Noelia Tarazona

subject

0301 basic medicine Oncology medicine.medical_specialty Bevacizumab Angiogenesis Colorectal cancer medicine.medical_treatment Drug Evaluation Preclinical Angiogenesis Inhibitors Disease Antibodies Monoclonal Humanized Toxicology Ramucirumab 03 medical and health sciences chemistry.chemical_compound Clinical Trials Phase II as Topic 0302 clinical medicine Internal medicine medicine Animals Humans Randomized Controlled Trials as Topic Pharmacology Chemotherapy Clinical Trials Phase I as Topic Neovascularization Pathologic business.industry Antibodies Monoclonal Cancer General Medicine medicine.disease Vascular endothelial growth factor Disease Models Animal 030104 developmental biology Clinical Trials Phase III as Topic chemistry 030220 oncology & carcinogenesis Colorectal Neoplasms business medicine.drug

description

Colorectal cancer is the third most common cancer worldwide. The prognosis of colorectal cancer patients still remains dismal and half of them will develop metastatic disease. Angiogenesis plays an essential role in colorectal tumorigenesis, and the VEGF pathway is one of the targets that has been validated up to now. The use of antiangiogenics along with chemotherapy has become an accepted standard for colorectal cancer.This review discusses the efficacy and safety profile of ramucirumab, a fully human immunoglobulin G1 monoclonal antibody against the vascular endothelial growth factor receptor-2 (VEGFR-2), for the treatment of second-line metastatic colorectal cancer upon progression to first-line chemotherapy including anti-angiogenics.Ramucirumab in combination with chemotherapy represents a valid option in second-line treatment of advanced colorectal cancer patients, who progressed on previous bevacizumab-based combinations. This agent demonstrates a similar benefit in terms of overall survival to other angiogenesis inhibitors (bevacizumab and ziv-aflibercept) used in this setting.

year	journal	country	edition	language
2016-03-10	Expert Opinion on Drug Metabolism & Toxicology

https://doi.org/10.1517/17425255.2016.1156084

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